The stimulation of the synthesis of collagen-1 by MBG is based on the inhibition of the nuclear transcription factor Fli1, which is a suppressor of the promoter of the Col1 gene responsible for the synthesis of procollagen-1 due to the activation of protein kinase C. Thus, the silencing of the Fli1 gene using inhibitory RNA should lead to consequences comparable with those in not only preeclampsia and chronic kidney diseases but also in advanced hypertension. This evidence concerns the gene FLI1 and Hypertension.