When CD8+ T cells from the same host were transduced to express three different TCRs (SILv44, R6C12, and T4H2) responding to the same HLA-A2-restricted peptide, we found that the resulting cytokine responses varied, suggesting that subtle changes in TCR structure can affect the resulting cytokine secretion patterns of host T cells and impact anti-tumor responses in ways that do not correlate with IFN-γ secretion, but rather with IL-17 expression levels [66]. The gene discussed is CD8A; the disease is neoplasm.