In those reports, autologous and allogenic DNTs were co-cultured in vitro with cancer cell lines and showed cytotoxicity that was mediated by perforine and granzyme B after a cell interaction induced by a high affinity TCR or by the activating immune receptor NKG2D, whose expression may have been modulated by PD1 inhibitors [11,12,13,14]. The gene discussed is GZMB; the disease is cancer.