In the mITT analysis, TNFα showed a non-significant interaction with group, with higher levels associated with more severe depression at post-treatment in metyrapone than placebo groups (β = 8.24 [95% CI −1.59, 18.01], standardised effect size (SES) = 0.36, p = 0.097). The gene discussed is TNF; the disease is depressive symptom measurement.