In total, 39/90 (43.3%) HSP probands were genetically characterized (Table 1 and Figure 3); the diagnostic rate was 56.7% in AD-HSP (17/30 families), and SPG4 was the most frequent form (16/17), with a novel SPG10 pathogenic variant found in one family [34]. The gene discussed is KIF5A; the disease is hereditary spastic paraplegia.