Regarding AR-HSP, a genetic diagnosis was made in 15/27 families (55.5%): in the SPG11 gene, mutations were the prevalent genetic etiology (six families, 42.8%), followed by SPG15 and SPG7 (six families each), SPG5, SPG35, SPG46, and SPG56 [35] (one patient each). This evidence concerns the gene CYP2U1 and hereditary spastic paraplegia.