TOP2A and non-small cell lung carcinoma: In total, 16 genes had extreme prognostic significance (p < 0.001): BIRC5, FOXM1, CEP55, NEK2, CDKN3, HMMR, TOP2A, TK1, HJURP, ANLN, CCNA2, TPX2, MELK, KIF11, and CCNB1. Moreover, based on the immunohistochemical staining results in Human Protein Atlas, protein levels of genes in the CCNB1-centered sub-module were consistent with their mRNA expression, i.e., their protein levels were also higher in NSCLC compared with normal samples (Figure 5f).