In particular, the top 10 ranked genes were MMP7, CDH5, CDH3, FOS, WASF3, TIMP3, PECAM1, ITGA1, CFP, CCNB1, ADAMTS8, ADAMTSL3, SEMA5A, THBS2, FGF2, EDN1, PPBP, and IGFBP3. Then, the un-weighted core network for NSCLC was constructed by extracting the 12 seed genes and the top 10% genes from node prioritization. The gene discussed is SEMA5A; the disease is non-small cell lung carcinoma.