Our Plexin-B3 IHC scores resonate with the Plexin-B3 expression in sequenced PC tumors evaluated through the online portal of MiPanda, where we observed significantly a higher Plexin-B3 expression (p = 1.51 × 10−13 in primary tumors in comparison with a normal pancreas. Here, PLXNB3 is linked to pachyonychia congenita.