Therefore, the aim of this article was to review the existing evidence about immunomodulatory drugs that have been used in patients with COVID-19, including corticosteroids, antimalarials, anti-TNF, anti-IL-1, anti-IL-6, baricitinib, intravenous immunoglobulins, and colchicine, in order to inform about efficacious therapeutic indications and potential clues to COVID-19 pathogenesis. This evidence concerns the gene TNF and COVID-19.