A study by Martinez-Quetglas et al. evaluated levels of IGF-2 mRNA and protein in patients with HCC and found that 15% of human HCC tissues had IGF-2 levels 20 times greater than levels in non-tumor liver tissues, and activation of the IGF-2 signaling pathway increased the expressions of AKT1 and MYC [83]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.