In addition, the presence of HBV DNA in the HCC genome was found in cases of sorafenib resistance mediated via activation of other signaling pathways including MAPK14 [230], NF-κB [247], and Wnt [229], which crosstalk with IGF/IGF-1R signaling [235,248,249]. This evidence concerns the gene IGF1R and hepatocellular carcinoma.