A study on HCC samples from Guangxi, China, confirmed the positive correlation between HCC and aflatoxin but evidence for an HBV-aflatoxin interaction modulating the p53 mutation [55] or for a hepatitis B surface antigen (HBsAg) and aflatoxin synergistic effect in HCC [56] was not clear. This evidence concerns the gene TP53 and hepatocellular carcinoma.