Oxidative stress in the liver promotes the secretion of cytokines and chemokines (IL-6, IL10, IL1β, and TNFα) [61,62,63,64] and activates several signaling pathways (Jak/STAT; NF-kB, and MAPK cascade) which are implicated in the initiation of HCC. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.