Recent publications demonstrate that the use of PDE inhibitors might be a valuable adjunctive treatment approach in the SARS-CoV-induced ARDS [194,203], beside standard interventions, such as lung-protective ventilation, prone positioning, neuromuscular blockade for a patient-ventilator synchrony, maintenance of a negative fluid balance, administration of antibiotics preventing secondary bacterial and fungal infections, and administration of antiviral drugs [207]. The gene discussed is ALDH7A1; the disease is acute respiratory distress syndrome.