PDE4A and fibrosis: In mice with a model of bleomycin-induced injury, other PDE4 inhibitor cilomilast attenuated a late stage of experimental fibrosis when it decreased a fibrosis degree, tended to restore a lung collagen, and increased a lung compliance, but showed no effect on the expression of remodeling markers, such as TGF-β1 and collagen type Ia1 [150].