In minipigs with sepsis, lisofylline pretreatment and treatment given 1 h after injection of bacteria attenuated sepsis-induced pulmonary hypertension, neutropenia, and hypoxemia, and reduced lung edema markers, TBARS concentration, and myeloperoxidase (MPO) activity, but these effects were not seen in the treatment given 2 h after the bacteria [72]. Here, MPO is linked to neutropenia.