One could hypothesize that these activated, tumor-specific T cells from spleens of Vaccine/Bintrafusp/SX-treated mice could mediate some degree of tumor control if adoptively transferred into MC38-CEA tumor-bearing mice; however, such experiments would not be able to reveal the full potential of this combination immunotherapy, which relies on tumor-localized effects mediated by SX-682 and bintrafusp alfa. Here, CEACAM5 is linked to neoplasm.