These data are in agreement with the flow cytometric analysis of MC38-CEA tumors, which demonstrated an increased number of infiltrating CD4+ effector/effector memory T cells as well as CD8+ effector/effector-memory T cells in Vaccine/Bintrafusp/SX-treated tumors versus tumor in the Bintrafusp/SX group. This evidence concerns the gene CD4 and neoplasm.