In this context, it has recently been demonstrated that the neuroprotective action of crocins evidenced in a preclinical glutamatergic model of schizophrenia was related to their ability to restore the expression of BDNF and that of the silent information regulator-1 (SIRT-1), a modulator of oxidative stress and inflammation, thus eliciting alleviation of the oxidative stress [51]. Here, BDNF is linked to schizophrenia.