ERK signaling dysfunction is related to a variety of neurological abnormalities such as Huntington’s disease (HD), Parkinson’s disease (PD) [16], Alzheimer’s disease (AD) [23], amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), stroke, ischemia [24], asthma [25] and cancer [26]. The gene discussed is MAPK1; the disease is Alzheimer disease.