However, in contrast to most cancer cells, where glutamine is converted to glutamate and then to α-ketoglutarate (αKG) through the catalysis of GLUD1, in PC, glutamine is mitochondrially converted to aspartate by GOT2 and then to oxaloacetate (OAA) as catalyzed by cytoplasmic aspartate transaminase (GOT1). The gene discussed is GOT2; the disease is cancer.