However, in contrast to most cancer cells, where glutamine is converted to glutamate and then to α-ketoglutarate (αKG) through the catalysis of GLUD1, in PC, glutamine is mitochondrially converted to aspartate by GOT2 and then to oxaloacetate (OAA) as catalyzed by cytoplasmic aspartate transaminase (GOT1). This evidence concerns the gene GLUD1 and cancer.