We used the following keywords and their combinations: “renin”, “angiotensin”, “chronic kidney disease”, “developmental programming”, “DOHaD”, “offspring”, “mother”, “nephrogenesis”, “nephron”, “prorenin receptor”, “aldosterone”, “mineralocorticoid receptor”, “pregnancy”, “progeny”, “reprogramming”, “angiotensinogen”, “angiotensin-converting enzyme”, and “hypertension”. The gene discussed is ACE; the disease is Hypertension.