In the majority of studies, adult offspring developed hypertension and kidney disease coinciding with increased expression of ACE [64,65,66,72,74,76,82,86] and AT1R [51,54,55,59,62,63,67,69,72,73,74,78,79,80,81,84], and ACE activity [73,77,88]. This evidence concerns the gene AGTR1 and hypertensive disorder.