ACE2 and hypertensive disorder: Table 1 shows adult offspring developed hypertension and kidney disease coinciding with downregulated non-classical RAAS pathway in several models of renal programming, including maternal low protein diet [61], maternal CKD [71], maternal diabetes [72], and glucocorticoid exposure model [87,88]. However, the reports were conflicting with increased ACE2 expression in the continuous light exposure model [74].