uPA and tPA receptors, such as uPAR, LRP1, integrins, and annexin II (AnxII), modulate intracellular signaling pathways, just like NF-κB, establishing a premetastatic niche [38,39], which is an environment prepared for tumor cell colonization in distant organ sites (Figure 2). Here, NFKB1 is linked to neoplasm.