In conclusion, increased immune cell infiltration of T and B cells as well as higher levels of PD-L1 expression in AciCCs in association with high-grade transformation, lymph node metastasis and unfavourable prognosis suggests a relevant interaction between tumour cells and immune cell infiltrates and warrants further exploration of the efficacy of immunotherapies in clinical studies with inclusion of high grade AciCCs only. Here, CD274 is linked to neoplasm.