HDAC1 and prostate adenocarcinoma: The expression of the epigenetic modifier gene HDAC1, which is part of a NOTCH signaling co-repressor complex [45], is not only repressed by miR-449a (Figure 3B,C), but also highly correlated to ERG in the ICGC-EOPC (r = 0.72, p < 2 × 10−16) and TCGA-PRAD data cohorts (r = 0.71, p < 2 × 10−16) (Figure 5A and Figure S7).