AKT1 and alcohol drinking: The Kyoto Encyclopedia of Genes and Genomes (KEGG) classification was found for 1037 DEGs that were further classified into the top twenty biochemical pathways according to the smallest q-value and the largest GeneNumber in pathway annotation (Figure 3).The GeneNumber and ratio of annotated genes of the top five pathways are systemic lupus erythematosus (33, 8.4%), alcoholism (38, 9.67%), transcriptional misregulation in cancers (22, 5.6%), PI3K–Akt signaling pathway (34, 8.65%) and complement and coagulation cascades (12, 3.05%).