With respect to the influence of inflammasome activation on the clinical outcome of COVID-19, it was found that (i) IL-18 levels, but not Casp1p20, were higher in patients who required mechanical ventilation; (ii) levels of Casp1p20 but not IL-18 were higher in patients with the severe form of COVID-19, and (iii) levels of IL-18, but not Casp1p20, were higher in lethal cases of COVID-19 when compared with survivors [79]. Here, IL18 is linked to COVID-19.