In conclusion, the knowledge gained from the characterization of the ZmLOX4 gene in maize defense against F. verticillioides and its influence on genes of the LOX, JA and GLV pathways, together with additional investigations, as hormonal and lipid profiles, will allow the employment of LOX genes and resistant genotypes, as Tzi18, to hamper fungal infection in maize via marker-assisted selection and genome editing approaches. This evidence concerns the gene LOX and fungal infectious disease.