Thus, for proving pharmacological activity of the plant-derived non-toxic AhR ligands Q and I3C, we applied two different protocols of chronic colitis causing alternatively a severe or a moderate course of colitis in the C57BL/6 WT or the C57BL/6 Ahr-/- mouse model resembling different outcomes of IBD in human patients (Figure 1). Here, AHR is linked to inflammatory bowel disease.