In an animal model of asthma, it was shown that resveratrol had a suppressive effect on asthmatic parameters as it inhibited the production of Th-2 cytokines like IL-4 and IL-5 in the plasma and bronchoalveolar lavage fluid, and caused suppression of airway hyperresponsiveness, eosinophilia, and hypersecretion of mucus [136]. This evidence concerns the gene IL4 and asthma.