Taken together, our phenotypic and histological analyses of HNSCC tumors in WT and Pi3kcg−/− mice demonstrate that host PI3K p110γ inhibition did not have a significant effect on tumor growth and metastasis in the orthotopic MOC2 mouse model of poorly immunogenic HNSCC. The gene discussed is PIK3CD; the disease is head and neck squamous cell carcinoma.