IL4 and neoplasm: To determine whether there were inherent deficiencies in T-cell ability to respond to oral tumor insult, we isolated T-cells from the lymph nodes and spleens of both tumor-bearing and non-tumor bearing mice and examined their ability to produce T-cells associated cytokines — IL-2, IL-4, IL-6, IL-10, IL-17, and IFN-γ —following CD3 stimulation.