Micallef et al. reported overexpression of MARCKS in nine of 18 (50%) studied MM cell lines [43]; in addition, in line with our present findings, Yang et al. reported increased MARCKS expression in bortezomib-refractory MM patients, as well as increased bortezomib sensitivity in bortezomib-resistant MM cells following inhibition of MARCKS phosphorylation [44]. This evidence concerns the gene MARCKS and Miyoshi myopathy.