PDX1 and pancreatic ductal adenocarcinoma: Furthermore, the spontaneous pancreas ductal adenocarcinoma animal (PDAC) model, LSL-KrasG12D/+; LSL-p53T172H/+; Pdx1-Cre (KPC), was bred with ROSA26-pGAGGs-LSL luciferase animals, resulting in a spontaneous bioluminescent PDAC animal model (KPC-Luc) in which spontaneous pancreas tumors developed that were bioluminescent [36].