CD4+ TCRαβ+ T helper cells (Th) are known to express the CD40L ligand that interacts with CD40 on dendritic cells, allowing secretion of several cytokines (IL-2, IL-15 and IFN γ) and activation of CD8+ cytotoxic T lymphocytes (CTLs), a T cell subset efficient in anti-tumor responses [142]. Here, CD4 is linked to neoplasm.