TRPV1 and Alzheimer disease: TRPV1 and TRPA1 are activated by diverse stimuli in addition to GPCR ligands, including extracellular pH, adenosine triphosphate (ATP), prostaglandins, oxidants, capsaicin, allyl isothiocyanate, heat and cold, and TRPV1 and TRPA1, which are involved in the pathology of AD and pruritus [11,12].