As expected, CRC tissue enriched immune-response-related gene sets, such as allograft rejection, interferon (IFN)-α response, IFN-γ response, inflammatory response, IL-6/JAK/STAT3, complement, and coagulation (Figure 4A, Table S1; NES = −1.43 FDR = 0.145; NES = −1.42 FDR = 0.150; NES = −1.48 FDR = 0.135; NES = −1.55 FDR = 0.119; NES = −1.44 FDR = 0.144; NES = −1.46 FDR = 0.138; NES = −1.52 FDR = 0.130, respectively). This evidence concerns the gene IL6 and colorectal carcinoma.