ACVR1 and fibrodysplasia ossificans progressiva: Dysregulation of BMP signalling is associated with many disease pathologies, an example of which is the ectopic bone forming disease fibrodysplasia ossificans progressivia (FOP) where a gain of function mutation in type II BMPR (ACVR1) leads to constitutively active kinase domain enhancing R-SMAD translocation to the nucleus [58].