TLR9 and paracoccidioidomycosis: In a model of experimental immunization, TLR 9−/− mice were found to produce more antibodies than the control mice, mostly of the IgG1 and IgG3 subtypes, demonstrating that TLR-9 plays a role in the protection induced by immunization with rPb27 and confirming the importance of TLR-9 in the initial protection against paracoccidioidomycosis [38].