Mild or moderate chronic forms of paracoccidioidomycosis are now believed to occur in the context of Th17/Th22 lymphocytes and a mixture of cytokines IL-17 and IL-22 (high levels), IFN-γ, TNF-α, IL-2 and IL-10 and IL-4 (variable levels) and with high levels of IgG1 antibodies. This evidence concerns the gene TNF and paracoccidioidomycosis.