There is a significant amount of literature concerning the impact of polymorphisms on AGO encoding genes and the risk of cancer; therefore, Dobrijevic et al. performed a meta-analysis to seek a general influence of AGO1 and AGO2 SNPs on neoplasia susceptibility based on eleven reports [98,109,113,114,115,116,117,118,119,120,121]. Here, FBXW7 is linked to cancer.