Interleukin-8 (IL-8), which are secreted as exosomes from CML cells, stimulate HUVECs in order to increase the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). This evidence concerns the gene VCAM1 and chronic myelogenous leukemia, BCR-ABL1 positive.