In a study by Chen et al., it was shown that antagonism of the IL-6/sIL-6R complex by IgG Fc linked gp130 (Fc-gp130) decreased STAT3 phosphorylation and attenuated the development of renal fibrosis by interfering with IL-6 trans-signaling [156]. The gene discussed is IL6ST; the disease is renal fibrosis.