Specifically, investigation into prognostic ability of IL-6 has been of interest as a G/C polymorphism at the -174 position in the promotor region of the IL-6 gene, resulting in IL-6 overexpression, has been linked to all-cause mortality in peritoneal dialysis (PD) patients [164], as well as elevated risk of cardiovascular disease incidence [165]. Here, IL6 is linked to kidney failure.