This function of local vascular tone modulator is lost in obesity related metabolic syndrome with evidence of fat hypertrophy, and increased production of inflammatory cytokines (TNF alfa, and IL6) resulting in increased oxidative stress and hypoxia (reversible by use of cytokines blockers, and free radical scavengers) [76,77]. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.