The expansion of visceral adipose tissue occurring during obesity correlates with an abnormal synthesis of vasoactive adipokines [63], increased NEFA, and proinflammatory cytokines release into the bloodstream that lead to a systemic low grade inflammation and impair vascular homeostasis towards an increased ET-1 system activity [64,65,66]. Here, EDN1 is linked to obesity due to melanocortin 4 receptor deficiency.