Furthermore, osteoporosis did not develop in premenopausal women and men younger than 50 years with HbS/β-thalassemia, but instead developed with age, as demonstrated by a compensatory decrease of osteoclastic cytokine, sRANKL, with a compensatory increase of the osteoblastic cytokine OPG. Here, TNFRSF11B is linked to osteoporosis.