FGF21 treatment in various mouse models of acute and chronic pancreatitis induced by caerulein, alcohol consumption, or endoscopic retrograde cholangiopancreatography radiocontrast dye prevented the onset of pancreatitis and alleviated symptoms, while acinar cell-specific deficiency or silencing of FGF21 or its co-receptor KLB blocked these beneficial effects [156,157]. This evidence concerns the gene FGF21 and chronic pancreatitis.