IGF1 and obesity due to melanocortin 4 receptor deficiency: Adipose tissues or adipocytes under obesity conditions demonstrate altered profiles of systemic and local levels of signaling molecules, including insulin, insulin-like growth factor 1 (IGF1), adipokines, cytokines, chemokines, growth factors, sex hormones, and nutrient substrate molecules, forming a pro-tumorigenic milieu [20,21].