CD8A and neoplasm: In addition, T cells in the TME of NBL, as defined by the presence of CD3+, CD4+, and CD8+ subpopulations, are associated with favorable clinical outcomes in MYCN-amplified NBL [12], and another study has similarly reported that increased cytotoxic tumor infiltration lymphocytes (TILs) in MYCN-non-amplified NBL is associated with the presence of activated NK/T cells and improved outcomes [13].