A significant interaction was found between dietary energy intake and FTO rs8050136 (p = 0.004), in which participants with a higher dietary energy intake had a more obvious effect of FTO rs8050136 on obesity compared to those with a lower dietary energy intake (OR = 1.77, 95%CI:1.20–2.62). This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.