These include Spon2, Adam19, Arntl, Cdkn1a, Cry2, Per2, Per3, Wee1, Rcan1, Slc41a3, Errfi1, and Bhlhe41, which are related to numerous cardiovascular and degenerative diseases of other organs as well as varying aging processes. Here, SPON2 is linked to neurodegenerative disease.