FOLH1 and neoplasm: Biodistribution studies of 177Lu-PSMA-617 and 177Lu-PSMA-I&T in mice bearing PC3 PIP or PC295 PDX prostate tumors demonstrated comparable tumor uptake at all time points, while 177Lu-PSMA-I&T had much higher (10–40 folds) renal uptake, resulting in an unfavorable tumor-to-kidney ratio [204,205].