They also showed that Smad signaling induces HMGA2 expression, responsible for the aggressiveness of cancer cells; in addition, they reported HMGA2 may regulate expression of Snail, Slug, δEF-1/ZEB-1, and SIP-1/ZEB-2 as well as Twist and E-cadherin during EMT [91]. Here, HMGA2 is linked to cancer.