The core of the pathway is currently described as a canonical kinase cascade of tumour suppressors, notably, the kinase Hippo (Hpo) in complex with Salvador (Sav) (MST1/2-SAV1 complex in mammals), which phosphorylates and activates a complex of the kinase Warts (Wts) and Mob as tumour-suppressor (Mats) (the LATS1/2-MOB1A/B complex in mammals), which, in turn, phosphorylates and inactivates its direct and physiological substrate Yorkie (Yki) (YAP/TAZ in mammals). The gene discussed is SAV1; the disease is neoplasm.