PDPN and cardiac hypertrophy: In the angiotensin II-mediated cardiac hypertrophy model, hearts isolated from Ccl19CreAtg5flox/flox mice were not only protected from increased collagen content, but also showed less gp38-expressing and Fosl-2-expressing fibroblasts and αSMA-positive myofibroblasts in comparison to controls (Figure 7C–E and Figure S4B,C).