We previously showed that cultured CLL cells released no detectable to low levels of VEGF (0–7 pg/mL/106 cells/48 h), IL-6 (0–40 pg/mL/106 cells/48 h), and NGAL (0–19 ng/mL/106 cells/48 h) [31,74], which were not altered by IFNs pretreatment [31] (B Bauvois, unpublished results). This evidence concerns the gene LCN2 and B-cell chronic lymphocytic leukemia.