Cytokines also deserve particular attention, not only because of their well-studied biology within the context of autoimmune disease and chronic inflammation, but also as a possible mechanism of damage in inflammatory response, given that many studies have tried to investigate the possible role of these molecules and suggest that people with DS demonstrate an incremented level of both pro- (IL-2, IL-1, IL-6, TNF-α) and anti-inflammatory cytokines (IL-10, IFN-γ) at baseline and after stimulation [24,25,26]. This evidence concerns the gene TNF and Dravet syndrome.