MBL2 and hyperinsulinemic hypoglycemia, familial, 4: Nevertheless, Eisen et al. analyzed the association between MBL deficiency and the outcome of IPD using data pooled from five studies with adults and one study with children and concluded that the risk of death was increased among MBL-deficient patients with S. pneumoniae infection (odds ratio, 5.62; 95% confidence interval, 1.27–24.92) after adjustment for bacteremia, comorbidities and age [74].