Relatedly, prior work from our labs demonstrated that an autophagic inducer, PI3K/mTOR inhibitor BEZ235, slows progression of HPV-positive anal cancers in a HPV16 E6/E7 mouse model [83], so protease inhibitors might also be studied in combination with autophagy inducers to determine if E6/E7 downregulation potentiates drugs developed to suppress this cancer-linked pathway. This evidence concerns the gene MTOR and anal carcinoma.