GO-based nanosheets loaded with 5-FU and modified with GE11 (efficient ligand for EGFR) were able to transfer the drug into EGFR-overexpressing HCT-116 cells effectively, and after irradiation accelerated oxidation of glutathione in the tumor cells was observed, resulting in destruction of the intracellular redox balance after irradiation; in a subcutaneous colorectal cancer bearing mouse model, the nanocomposite exhibited 90% tumor inhibition [229]. The gene discussed is EGFR; the disease is neoplasm.