HIF1A and cancer: Carboxylated GO conjugated with trimethyl CS hyaluronate NPs loaded with hypoxia-inducible factor (HIF)-1α-siRNA and dinaciclib (inhibitor of cyclin-dependent kinases (CDK1, CDK2, CDK5, and CDK9, Figure 11) considerably restrained the CDKs/HIF-1α and reduced the proliferation, migration, angiogenesis, and colony formation in tumor cells, suggesting that such dual drug/gene delivery in cancer treatment could be successfully used as an anticancer treatment strategy [203].