DOX-loaded GO, which was modified by Pluronic® F68, FA and transferrin, allowing dual-targeting, showed controllable drug delivery performance with no toxicity, exhibited a higher inhibitory efficiency against human hepatocellular carcinoma SMMC-7721 cells than a single target drug delivery system without transferrin functionalization, and showed sustained release, being able to decrease the drug release rate in blood circulation over time and enhance drug concentration in or near a targeted tumor [208]. The gene discussed is TF; the disease is hepatocellular carcinoma.