IL-1β levels are also correlated with the percentages of periodontopathogenic bacteria in the saliva of patients with oral cancer; moreover, IL-1β stimulation regulates multiple immunogenic responses in the TME, such as enhancing IL-6 and IL-8 expression, promoting M2 macrophage polarization, and inducing Myc-dependent angiogenesis [15,121,122]. This evidence concerns the gene IL1B and lip and oral cavity carcinoma.